2 edition of Nephrotoxicity (Monographs in Applied Toxicology) found in the catalog.
Nephrotoxicity (Monographs in Applied Toxicology)
October 20, 1982
by John Wiley and Sons Ltd
Written in English
|The Physical Object|
|Number of Pages||544|
A review on colistin nephrotoxicity Article (PDF Available) in European Journal of Clinical Pharmacology 71(7) May with 2, Reads How we measure 'reads'. A well-known side effect of cisplatin is nephrotoxicity, which is the primary dose-limiting toxicity. Hydration in conjunction with appropriate diuresis can decrease the incidence of nephrotoxicity. Objectives: This article aims to identify best practices in supportive therapy for patients receiving cisplatin by: 8.
ISBN: OCLC Number: Description: xv, pages: illustrations ; 24 cm: Contents: Isolated renal cells in the study of nephron heterogeneity and nephrotoxicity / Lawrence H. Lash --Use of cultured renal epithelial cells in in vitro assessment of xenobiotic-induced nephrotoxicity / Gerhard Gstraunthaler and Walter Pfaller --Epithelial cell fusion of normal and. The efficacy of ifosfamide (IFO), an antineoplastic drug, is severely limited by a high incidence of nephrotoxicity of unknown etiology. We hypothesized that inhibition of complex I (C-I) by chloroacetaldehyde (CAA), a metabolite of IFO, is the chief cause of nephrotoxicity, and that agmatine (AGM), which we found to augment mitochondrial oxidative phosphorylation and β-oxidation, would Cited by:
Homeostasis, Nephrotoxicity, and Renal Anomalies in the Newborn Proceedings of Pediatric Nephrology Seminar XI held at Bal Harbour, Florida January 29–February 2, . ISBN: X OCLC Number: Notes: "Proceeding of the Third International Symposium on Nephrotoxicity: Extrapolation from Animals to Man and In Vitro to In Vivo, held August , , at the University of Surrey, Guildford, Surrey, United Kingdom"--Title page verso.
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Nephrotoxicity is a significant treatment complication that has limited the clinical utility of cyclosporine. A number of recent studies have examined novel pathways and potential therapeutic targets in the prevention of cyclosporine nephrotoxicity. With the advent of effective cytotoxic chemotherapy, attention has turned to the side effects of these widely used agents (Table ).
These side effects include tumor lysis syndrome, paraneoplastic glomerulonephritis, obstructive uropathy, and nephrotoxicity with renal failure and electrolyte disturbances. These are more common in the geriatric population secondary to polypharmacy/drug Author: Christopher J.
Logothetis, Vasily Assikis, Jose E. Sarriera. This page includes the following topics and synonyms: Nephrotoxic Drug, Nephrotoxin, Drug-induced Nephrotoxicity, Medication Causes of Acute Kidney Injury, Medication Causes of Acute Tubular Necrosis, Medication Causes of Interstitial Nephritis, Medication Causes of Glomerulonephritis, Medication Causes of Prerenal Failure, Medication Causes of Postrenal Failure, Toxic Nephropathy, Drug.
Nephrotoxicity is the principal adverse event associated with systemic administration of cidofovir. 94,95 Cidofovir concentrates in renal cells in amounts times greater than in other tissues, producing severe nephrotoxicity involving the proximal convoluted tubule when concomitant hydration and administration of probenecid are not employed.
Nephrotoxicity can be defined as the adverse effect of substances on renal function (Perazella, ).These substances can include molds and fungi, cancer therapeutics such as cisplatin, antibiotics such as aminoglycosides, metals such as mercury, arsenic and lead, and drugs of Cited by: Patients at highest risk of drug-induced nephrotoxicity are those with one or more of the following: age older than 60 years, baseline renal insufficiency (e.g., GFR Cited by: There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed.
Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or. Drug-induced nephrotoxicity is a renal dysfunction that occurs as a result of exposure to nephrotoxic drugs. It is a common problem in certain clinical situations such as underlying renal dysfunction, cardiovascular disease, diabetes, and sepsis.
Drugs can cause mild to moderate nephrotoxic problems such as intrarenal obstruction, interstitial nephritis, nephrotic syndrome, acid-base and fluid Cited by: 1.
Nephrotoxicity: Assessment and Pathogenesis by F. Bonner and a great selection of related books, art and collectibles This is an ex-library book and may have the usual library/used-book markings book has hardback covers.
In fair condition, suitable as a study copy. No dust jacket. Please note the Image in this listing is a. The principle that should guide clinicians in the use of potentially nephrotoxic agents in the treatment of cancer is close monitoring for the development of renal toxicity, its early detection, and its management.
The wide range of renal insults induced by cytotoxic drugs complicates the selection of the appropriate study to monitor potential nephrotoxicity Clinicians apply similar Author: Christopher J.
Logothetis, Vasily Assikis, Jose E. Sarriera. The kidneys normally receive 20% of the cardiac output. Drugs are filtered and/or secreted and then progressively concentrated in the urine. Therefore, these organs are especially vulnerable to the toxic effects of many drugs, including chemotherapy toxicity is often a dose-limiting adverse effect of chemotherapy.
Chemotherapy agents can affect the microvasculature, the glomerulus. Nephrotoxicity is a significant concern in pediatrics with 16% of hospitalized AKI events being attributable primarily to a drug.
The epidemiology of tubular disorders is unclear as a standard definition is lacking and many published reports document tubular dysfunction leading to by: Nephrotoxicity is toxicity in the is a poisonous effect of some substances, both toxic chemicals and medications, on renal are various forms, and some drugs may affect renal function in more than one way.
Nephrotoxins are substances displaying nephrotoxicity. Nephrotoxicity should not be confused with the fact that some medications have a predominantly renal. Although uncommon, the widespread use of NSAIDs means that renal complications are likely to be seen frequently Two isoforms of COX (COX-1 and COX-2) have been identified in mammalian cells.
COX-1, which is constitutively expressed, mediates gastric cytoprotection and vascular homeostasis. COX-2 expression is regulated by salt and water intake, medullary tonicity, growth factors.
Pathophysiology of Nephrotoxic Acute Renal Failure H umans are exposed intentionally and unintentionally to a variety of diverse chemicals that harm the kidney. As the list of drugs, natural products, industrial chemicals and environ-mental pollutants that cause nephrotoxicity has increased, it File Size: KB.
Nephrotoxicity is an important and preventable cause of nephrotoxin induced acute kidney injury (AKI) as well as chronic kidney disease (CKD). Drugs and toxins may cause renal injury based on several pathophysiological mechanisms. The spectrum of injury may vary from subtle to severe.
The potentially nephrotoxic antibiotics in current clinical use are neomycin, kanamycin, paromomycin, bacitracin, the polymyxins (polymyxin B, and colistin), and amphotericin B. Nephrotoxicity was reported with early lots of streptomycin, but the drug now commercially available does not appear to have this property.
Fortunately, the nephrotoxicity of each of these drugs appears to be Cited by: Aminoglycoside-Induced Nephrotoxicity Article (PDF Available) in Journal of Pharmacy Practice 27(6) September with 1, Reads How we measure 'reads'. Abstract. Contrast media nephrotoxicity refers to a condition in which impairment of renal function occurs following intravascular administration of a contrast medium in the absence of.
Nephrotoxicity mechanism 1. Nephrotoxic Mechanisms of Drugs and Environmental Toxins 2. Nephrotoxic Mechanisms of Drugs and Environmental Toxins Edited by GEORGE A. PORTER, M.D. University of Oregon Health Science Center Portland.
Background: Cisplatin has been used as a chemotherapeutic agent to treat many different cancers. A well-known side effect of cisplatin is nephrotoxicity, which is the primary dose-limiting toxicity. Hydration in conjunction with appropriate diuresis can decrease the incidence of nephrotoxicity.
Objectives: This article aims to identify best practices in supportive therapy for patients.This chapter will give the environmental and occupational health professional information about: the importance of kidney functions; how toxic agents disrupt kidney functions; measurements performed to determine kidney dysfunctions; and occupational and environmental agents that cause kidney by: 5.Drug-Induced Kidney Disease.
Drug-induced nephrotoxicity is caused by nephrotoxic drugs that cause kidney damage. These drugs need to be identified and avoided to prevent kidney injury.